Complete dosing information for linaclotide
Medical guidance required: Dosing information here is for educational purposes. Your healthcare provider will determine the appropriate dose based on your specific condition, kidney function, other medications, and medical history. Never adjust your dose without consulting your doctor or pharmacist.
IBS-C: 290 mcg orally once daily, taken on an empty stomach at least 30 minutes before the first meal of the day. CIC: 72 mcg or 145 mcg orally once daily, taken on an empty stomach at least 30 minutes before the first meal of the day. The 145 mcg dose is typically the starting dose for CIC, with 72 mcg available for patients who experience excessive diarrhea. No dose adjustment is required for renal impairment or hepatic impairment as systemic absorption is negligible.
Contraindicated in pediatric patients 6 years of age and younger due to risk of serious dehydration. Use should be avoided in patients 6 to 17 years of age. Safety and effectiveness have not been established in pediatric patients.