4 known interactions • 0 major • 4 moderate • 0 minor
Always disclose all medications to your healthcare providers — prescription medicines, OTC medications, vitamins, and herbal supplements. This list may not include every possible interaction. Use our Medicine Interaction Checker to screen your complete medication list.
Potentially life-threatening or causing permanent damage. Avoid combination.
May worsen condition or require dose adjustment. Monitor closely.
Usually limited clinical effect. Manage with routine monitoring.
Oral hypoglycemics (sulfonylureas, meglitinides)
Additive hypoglycemia risk.
Management: Adjust doses and monitor blood glucose closely when combining.
Beta-blockers (especially non-selective)
May mask early hypoglycemia symptoms (tachycardia, tremor) but not sweating.
Management: Counsel patients to watch for sweating as a remaining warning sign.
Thiazolidinediones (pioglitazone)
Increased risk of fluid retention and heart failure when combined with insulin.
Management: Use cautiously; monitor weight, edema, and dyspnea.
Alcohol
Increases and prolongs hypoglycemia risk by suppressing hepatic gluconeogenesis.
Management: Limit alcohol; pair with food and monitor glucose.
Always ask your pharmacist about potential interactions with food, alcohol, and supplements specific to Lantus. Some medicines have significant interactions with grapefruit juice, high-fat meals, dairy products, or vitamin K-rich foods.