4 known interactions • 1 major • 2 moderate • 1 minor
Always disclose all medications to your healthcare providers — prescription medicines, OTC medications, vitamins, and herbal supplements. This list may not include every possible interaction. Use our Medicine Interaction Checker to screen your complete medication list.
Potentially life-threatening or causing permanent damage. Avoid combination.
May worsen condition or require dose adjustment. Monitor closely.
Usually limited clinical effect. Manage with routine monitoring.
Corticosteroids
Steroids cause significant hyperglycemia, often requiring substantial insulin dose increases.
Management: Monitor glucose closely; expect to increase insulin dose (sometimes dramatically) when corticosteroids are added.
Antidiabetic medications (metformin, sulfonylureas, GLP-1 RAs)
Additive blood glucose-lowering effect — generally intended for combination therapy, but requires monitoring for hypoglycemia.
Management: Monitor blood glucose; titrate insulin and other agents to target glucose goals.
Beta-blockers
Beta-blockers mask tachycardia (hypoglycemia warning) and may prolong hypoglycemia.
Management: Monitor glucose closely; educate patients that sweating is a retained symptom.
ACE inhibitors
May enhance blood glucose lowering effect of insulin (improved insulin sensitivity).
Always ask your pharmacist about potential interactions with food, alcohol, and supplements specific to Insulin Glargine. Some medicines have significant interactions with grapefruit juice, high-fat meals, dairy products, or vitamin K-rich foods.