3 known interactions • 2 major • 1 moderate • 0 minor
Always disclose all medications to your healthcare providers — prescription medicines, OTC medications, vitamins, and herbal supplements. This list may not include every possible interaction. Use our Medicine Interaction Checker to screen your complete medication list.
Potentially life-threatening or causing permanent damage. Avoid combination.
May worsen condition or require dose adjustment. Monitor closely.
Usually limited clinical effect. Manage with routine monitoring.
Anticoagulants
Increased bleeding risk
Management: Monitor closely for signs of bleeding
Antiplatelet agents
Increased bleeding risk
Management: Use with caution; monitor for bleeding
CYP3A4 inhibitors
May increase ibrutinib levels
Management: Reduce dose or monitor for toxicity
Always ask your pharmacist about potential interactions with food, alcohol, and supplements specific to Imbruvica. Some medicines have significant interactions with grapefruit juice, high-fat meals, dairy products, or vitamin K-rich foods.