7 known interactions • 2 major • 5 moderate • 0 minor
Always disclose all medications to your healthcare providers — prescription medicines, OTC medications, vitamins, and herbal supplements. This list may not include every possible interaction. Use our Medicine Interaction Checker to screen your complete medication list.
Potentially life-threatening or causing permanent damage. Avoid combination.
May worsen condition or require dose adjustment. Monitor closely.
Usually limited clinical effect. Manage with routine monitoring.
amiodarone
Amiodarone can raise plasma flecainide concentrations two-fold or more by inhibiting CYP2D6; reduce the flecainide dose by about 50% and monitor for proarrhythmia and QRS widening.
verapamil
Combining flecainide with verapamil (or diltiazem) produces additive negative inotropic and conduction-slowing effects, increasing the risk of heart failure, AV block, and hypotension; concurrent use is generally discouraged.
digoxin
Flecainide increases plasma digoxin levels by roughly 13% to 19%; monitor digoxin levels and watch for signs of digoxin toxicity.
metoprolol
Beta-blockers add to the negative inotropic and conduction-slowing effects of flecainide and can raise its plasma levels; combine cautiously with monitoring for bradycardia, AV block, and reduced cardiac output.
fluoxetine
Strong CYP2D6 inhibitors such as fluoxetine, paroxetine, quinidine, and bupropion reduce flecainide clearance and increase its plasma concentration, raising the risk of toxicity; consider dose reduction and monitoring.
carvedilol
As both a beta-blocker and a CYP2D6 inhibitor, carvedilol can increase flecainide exposure and add negative inotropic effects; monitor cardiac function and consider a lower flecainide dose.
dofetilide
Concurrent use with other antiarrhythmics such as dofetilide, sotalol, or disopyramide increases the risk of additive conduction abnormalities and proarrhythmia; combine only under specialist supervision with ECG monitoring.
Always ask your pharmacist about potential interactions with food, alcohol, and supplements specific to Flecainide. Some medicines have significant interactions with grapefruit juice, high-fat meals, dairy products, or vitamin K-rich foods.