3 known interactions • 3 major • 0 moderate • 0 minor
Always disclose all medications to your healthcare providers — prescription medicines, OTC medications, vitamins, and herbal supplements. This list may not include every possible interaction. Use our Medicine Interaction Checker to screen your complete medication list.
Potentially life-threatening or causing permanent damage. Avoid combination.
May worsen condition or require dose adjustment. Monitor closely.
Usually limited clinical effect. Manage with routine monitoring.
Benzodiazepines
Risk of severe respiratory depression and death
Management: Avoid combination; if necessary, patient requires close monitoring
CNS depressants
Additive CNS depression
Management: Avoid or use with extreme caution
CYP3A4 inhibitors
May increase fentanyl levels and overdose risk
Management: Monitor closely for signs of overdose
Always ask your pharmacist about potential interactions with food, alcohol, and supplements specific to Fentanyl Patch. Some medicines have significant interactions with grapefruit juice, high-fat meals, dairy products, or vitamin K-rich foods.