Complete adverse effect profile including incidence rates and management
Important Safety Information
This is not a complete list of all possible side effects. Contact your healthcare provider if you experience any unexpected symptoms. For serious or life-threatening side effects, seek emergency medical attention immediately.
ADVERSE REACTIONS Gastrointestinal Anorexia, malaise, abdominal discomfort or pain, dysphagia, nausea, vomiting, and diarrhea have occurred.
These are more frequent with large doses or after one to three months of continuous therapy.
A few patients have had sudden onset of profuse, watery diarrhea.
Discontinue EDECRIN if diarrhea is severe and do not give it again.
Gastrointestinal bleeding has occurred in some patients.
Rarely, acute pancreatitis has been reported.
Metabolic Reversible hyperuricemia and acute gout have been reported.
Acute symptomatic hypoglycemia with convulsions occurred in two uremic patients who received doses above those recommended.
Hyperglycemia has been reported.
Rarely, jaundice and abnormal liver function tests have been reported in seriously ill patients receiving multiple drug therapy, including EDECRIN.
WARNINGS The effects of EDECRIN on electrolytes are related to its renal pharmacologic activity and are dose dependent.
The possibility of profound electrolyte and water loss may be avoided by weighing the patient throughout the treatment period, by careful adjustment of dosage, by initiating treatment with small doses, and by using the drug on an intermittent schedule when possible.
When excessive diuresis occurs, the drug should be withdrawn until homeostasis is restored.
When excessive electrolyte loss occurs, the dosage should be reduced or the drug temporarily withdrawn.
Initiation of diuretic therapy with EDECRIN in the cirrhotic patient with ascites is best carried out in the hospital.
Like all medications, Edecrin can cause side effects. However, not everyone who takes this medication will experience them. Many side effects are dose-dependent and may improve as your body adjusts to the medication. Others may require dose adjustment or medical attention.
Contact your healthcare provider promptly if you experience:
Seek immediate emergency medical care if you experience signs of: