Complete adverse effect profile including incidence rates and management
Important Safety Information
This is not a complete list of all possible side effects. Contact your healthcare provider if you experience any unexpected symptoms. For serious or life-threatening side effects, seek emergency medical attention immediately.
ADVERSE REACTIONS See BOXED WARNINGS , WARNINGS and PRECAUTIONS .
The following additional adverse reactions have been reported with estrogens and/or progestin therapy.
Genitourinary system Changes in vaginal bleeding pattern and abnormal withdrawal bleeding or flow;
breakthrough bleeding, spotting;
dysmenorrhea;
increase in size of uterine leiomyomata;
vaginitis including vaginal candidiasis;
change in amount of cervical secretion;
changes in cervical ectropion;
ovarian cancer;
WARNINGS See BOXED WARNINGS
Cardiovascular disorders Estrogen and estrogen/progestin therapy have been associated with an increased risk of cardiovascular events such as myocardial infarction and stroke, as well as venous thrombosis and pulmonary embolism (venous thromboembolism or VTE).
Should any of these occur or be suspected, estrogens should be discontinued immediately.
Risk factors for arterial vascular disease (e.g., hypertension, diabetes mellitus, tobacco use, hypercholesterolemia, and obesity) and/or venous thromboembolism (e.g., personal history or family history of VTE, obesity, and systemic lupus erythematosus) should be managed appropriately.
Coronary heart disease and stroke In the Women's Health Initiative (WHI) study, an increase in the number of myocardial infarctions and strokes has been observed in women receiving CE compared to placebo.
Like all medications, Depo-Estradiol can cause side effects. However, not everyone who takes this medication will experience them. Many side effects are dose-dependent and may improve as your body adjusts to the medication. Others may require dose adjustment or medical attention.
Contact your healthcare provider promptly if you experience:
Seek immediate emergency medical care if you experience signs of: