Complete adverse effect profile including incidence rates and management
Important Safety Information
This is not a complete list of all possible side effects. Contact your healthcare provider if you experience any unexpected symptoms. For serious or life-threatening side effects, seek emergency medical attention immediately.
ADVERSE REACTIONS Increased Heart Rate, Blood Pressure, and Ventricular Ectopic Activity A 10 to 20-mm Hg increase in systolic blood pressure and an increase in heart rate of 5 to 15 beats/minute have been noted in most patients (see WARNINGS regarding exaggerated chronotropic and pressor effects).
Approximately 5% of adult patients have had increased premature ventricular beats during infusions.
These effects are dose related.
Hypotension Precipitous decreases in blood pressure have occasionally been described in association with dobutamine therapy.
Decreasing the dose or discontinuing the infusion typically results in rapid return of blood pressure to baseline values.
In rare cases, however, intervention may be required and reversibility may not be immediate.
Stress Cardiomyopathy Stress cardiomyopathy has been reported with dobutamine in association with cardiac stress testing.
Reactions at Sites of Intravenous Infusion Phlebitis has occasionally been reported.
Local inflammatory changes have been described following inadvertent infiltration.
Miscellaneous Uncommon Effects The following adverse effects have been reported in 1% to 3% of adult patients: nausea, headache, anginal pain, nonspecific chest pain, palpitations, and shortness of breath.
WARNINGS Increase in Heart Rate or Blood Pressure Dobutamine Hydrochloride in 5% Dextrose Injection may cause a marked increase in heart rate or blood pressure, especially systolic pressure.
Approximately 10% of adult patients in clinical studies have had rate increases of 30 beats/minute or more, and about 7.5% have had a 50-mm Hg or greater increase in systolic pressure.
Usually, reduction of dosage reverses these effects.
Because dobutamine facilitates atrioventricular conduction, patients with atrial fibrillation are at risk of developing rapid ventricular response.
Patients with preexisting hypertension appear to face an increased risk of developing an exaggerated pressor response.
Like all medications, Dobutamine Hydrochloride In Dextrose can cause side effects. However, not everyone who takes this medication will experience them. Many side effects are dose-dependent and may improve as your body adjusts to the medication. Others may require dose adjustment or medical attention.
Contact your healthcare provider promptly if you experience:
Seek immediate emergency medical care if you experience signs of: