Complete adverse effect profile including incidence rates and management
Important Safety Information
This is not a complete list of all possible side effects. Contact your healthcare provider if you experience any unexpected symptoms. For serious or life-threatening side effects, seek emergency medical attention immediately.
ADVERSE REACTIONS Dose-limiting toxicity includes myelosuppression and cardiotoxicity (see WARNINGS section).
Other reactions include: Cutaneous Reversible alopecia occurs in most patients.
Rash, contact dermatitis and urticaria have occurred rarely.
Gastrointestinal Acute nausea and vomiting occur but are usually mild.
Antiemetic therapy may be of some help.
Mucositis may occur 3 to 7 days after administration.
Diarrhea and abdominal pain have occasionally been reported.
Local If extravasation occurs during administration, severe local tissue necrosis, severe cellulitis, thrombophlebitis, or painful induration can result.
Acute Reactions Rarely, anaphylactoid reaction, fever, and chills can occur.
Hyperuricemia may occur, especially in patients with leukemia, and serum uric acid levels should be monitored.
WARNINGS Bone Marrow Daunorubicin hydrochloride is a potent bone marrow suppressant.
Suppression will occur in all patients given a therapeutic dose of this drug.
Therapy with daunorubicin hydrochloride should not be started in patients with pre-existing drug-induced bone marrow suppression unless the benefit from such treatment warrants the risk.
Persistent, severe myelosuppression may result in superinfection or hemorrhage.
Cardiac Effects Special attention must be given to the potential cardiac toxicity of daunorubicin hydrochloride, particularly in infants and children.
Like all medications, Daunorubicin Hydrochloride can cause side effects. However, not everyone who takes this medication will experience them. Many side effects are dose-dependent and may improve as your body adjusts to the medication. Others may require dose adjustment or medical attention.
Contact your healthcare provider promptly if you experience:
Seek immediate emergency medical care if you experience signs of: