6 known interactions • 4 major • 2 moderate • 0 minor
Always disclose all medications to your healthcare providers — prescription medicines, OTC medications, vitamins, and herbal supplements. This list may not include every possible interaction. Use our Medicine Interaction Checker to screen your complete medication list.
Potentially life-threatening or causing permanent damage. Avoid combination.
May worsen condition or require dose adjustment. Monitor closely.
Usually limited clinical effect. Manage with routine monitoring.
MAO inhibitors (phenelzine, tranylcypromine, linezolid)
Bupropion component inhibits MAO indirectly; combination raises risk of hypertensive crisis and seizures.
Management: Contraindicated. Do not use within 14 days of stopping an MAOI.
Opioid analgesics / opioid agonist therapy (methadone, buprenorphine)
Naltrexone component blocks opioid receptors; renders opioid analgesia ineffective and may precipitate acute opioid withdrawal.
Management: Do not use Contrave in patients currently taking or dependent on opioids. Opioid-free for ≥7–10 days required.
Other bupropion-containing products (Wellbutrin, Zyban, Aplenzin)
Duplicate bupropion exposure increases seizure risk.
Management: Contraindicated — never combine. Use only one bupropion-containing product.
Alcohol / benzodiazepines / other CNS depressants
Abrupt cessation of alcohol or sedatives during bupropion therapy significantly lowers the seizure threshold.
Management: Minimize alcohol. Do not abruptly stop alcohol or benzodiazepines while taking Contrave.
CYP2B6 inhibitors (clopidogrel, ticlopidine, paroxetine)
Increase bupropion plasma concentrations, raising risk of seizures and adverse effects.
Management: Avoid if possible; if unavoidable, use the lowest effective bupropion dose and monitor closely.
Antihypertensives (beta-blockers, clonidine)
Bupropion inhibits CYP2D6, which metabolizes some beta-blockers; naltrexone may alter blood pressure.
Management: Monitor blood pressure closely; metoprolol / propranolol dose adjustment may be needed.
Always ask your pharmacist about potential interactions with food, alcohol, and supplements specific to Contrave. Some medicines have significant interactions with grapefruit juice, high-fat meals, dairy products, or vitamin K-rich foods.