Complete adverse effect profile including incidence rates and management
Important Safety Information
This is not a complete list of all possible side effects. Contact your healthcare provider if you experience any unexpected symptoms. For serious or life-threatening side effects, seek emergency medical attention immediately.
ADVERSE REACTIONS Gastrointestinal The most common adverse reactions are confined to the gastrointestinal tract.
To achieve minimal GI disturbance with an optimal LDL-C lowering effect, a gradual increase of dosage starting with 2 grams, once or twice daily is recommended.
Constipation is the major single complaint and at times is severe.
Most instances of constipation are mild, transient, and controlled with standard treatment.
Increased fluid intake and inclusion of additional dietary fiber should be the first step;
a stool softener may be added if needed.
Some patients require decreased dosage or discontinuation of therapy.
Hemorrhoids may be aggravated.
Other, less frequent gastrointestinal complaints consist of abdominal discomfort (abdominal pain and cramping), intestinal gas (bloating and flatulence), indigestion and heartburn, diarrhea and loose stools, and nausea and vomiting.
Bleeding hemorrhoids and blood in the stool have been infrequently reported.
Like all medications, Colestipol Hydrochloride can cause side effects. However, not everyone who takes this medication will experience them. Many side effects are dose-dependent and may improve as your body adjusts to the medication. Others may require dose adjustment or medical attention.
Contact your healthcare provider promptly if you experience:
Seek immediate emergency medical care if you experience signs of: