4 known interactions • 1 major • 3 moderate • 0 minor
Always disclose all medications to your healthcare providers — prescription medicines, OTC medications, vitamins, and herbal supplements. This list may not include every possible interaction. Use our Medicine Interaction Checker to screen your complete medication list.
Potentially life-threatening or causing permanent damage. Avoid combination.
May worsen condition or require dose adjustment. Monitor closely.
Usually limited clinical effect. Manage with routine monitoring.
Calcium channel blockers (verapamil, diltiazem)
Additive AV nodal blocking, risk of severe bradycardia and heart block.
Management: Avoid non-dihydropyridine CCBs with carvedilol. If required, monitor closely.
Insulin / antidiabetic medicines
Beta-blockade masks tachycardia (a key hypoglycemia symptom); may prolong hypoglycemic episodes. Non-selective beta-blockers also inhibit glycogenolysis.
Management: Monitor blood glucose closely; advise diabetic patients. Carvedilol may attenuate these effects less than other non-selective beta-blockers.
CYP2D6 inhibitors (fluoxetine, paroxetine, quinidine)
CYP2D6 inhibitors increase carvedilol plasma levels, potentially causing excessive bradycardia or hypotension.
Management: Monitor vital signs; reduce carvedilol dose if needed.
Digoxin
Both carvedilol and digoxin slow heart rate — additive bradycardia risk. Carvedilol may also slightly increase digoxin levels.
Management: Monitor heart rate and digoxin levels.
Always ask your pharmacist about potential interactions with food, alcohol, and supplements specific to Carvedilol. Some medicines have significant interactions with grapefruit juice, high-fat meals, dairy products, or vitamin K-rich foods.