Complete adverse effect profile including incidence rates and management
Important Safety Information
This is not a complete list of all possible side effects. Contact your healthcare provider if you experience any unexpected symptoms. For serious or life-threatening side effects, seek emergency medical attention immediately.
ADVERSE REACTIONS Carbidopa has not been demonstrated to have any overt pharmacodynamic actions in the recommended doses.
The only adverse reactions that have been observed have been with concomitant use of carbidopa with other drugs such as levodopa, and with carbidopa-levodopa combination products.
When carbidopa is administered concomitantly with levodopa or carbidopa-levodopa combination products, the most common adverse reactions have included dyskinesias such as choreiform, dystonic, and other involuntary movements, and nausea.
Other adverse reactions reported with carbidopa when administered concomitantly with levodopa alone or carbidopa-levodopa combination products were psychotic episodes including delusions, hallucinations, and paranoid ideation, depression with or without development of suicidal tendencies, and dementia.
Convulsions also have occurred;
however, a causal relationship with concomitant use of carbidopa and levodopa has not been established.
The following other adverse reactions have been reported with levodopa and carbidopa-levodopa combination products.
These same adverse reactions may also occur when carbidopa is administered with these products.
Body as a Whole: abdominal pain and distress, asthenia, chest pain, fatigue.
Cardiovascular: cardiac irregularities, hypertension, myocardial infarction, hypotension including orthostatic hypotension, palpitation, phlebitis, syncope.
WARNINGS Carbidopa has no antiparkinsonian effect when given alone.
It is indicated for use with carbidopa-levodopa or levodopa.
carbidopa does not decrease adverse reactions due to central effects of levodopa.
When carbidopa is to be given to carbidopa-naive patients who are being treated with levodopa alone, the two drugs should be given at the same time.
At least twelve hours should elapse between the last dose of levodopa and initiation of therapy with carbidopa and levodopa in combination.
Like all medications, Carbidopa can cause side effects. However, not everyone who takes this medication will experience them. Many side effects are dose-dependent and may improve as your body adjusts to the medication. Others may require dose adjustment or medical attention.
Contact your healthcare provider promptly if you experience:
Seek immediate emergency medical care if you experience signs of: