Complete dosing information for BUPROPION HYDROBROMIDE
Medical guidance required: Dosing information here is for educational purposes. Your healthcare provider will determine the appropriate dose based on your specific condition, kidney function, other medications, and medical history. Never adjust your dose without consulting your doctor or pharmacist.
2 DOSAGE AND ADMINISTRATION General • Increase dose gradually to reduce seizure risk. ( 2.1 , 5.3 ) Major Depressive Disorder • Starting dose: 174 mg once daily (equivalent to 150 mg bupropion HCl). Usual target dose: 348 mg once daily (equivalent to 300 mg bupropion HCl). ( 2.3 ) • After 4 days, may increase the dose to 348 mg once daily. ( 2.3 ) Seasonal Affective Disorder • Initiate treatment in the autumn prior to onset of seasonal depressive symptoms. ( 2.4 ) • Starting dose: 174 mg once daily (equivalent to 150 mg bupropion HCl). Usual target dose: 348 mg once daily (equivalent to 300 mg bupropion HCl). ( 2.4 ) • After one week, may increase the dose to 348 mg once daily. ( 2.4 ) • Continue treatment through the winter season. ( 2.4 ) Hepatic Impairment • Moderate to severe hepatic impairment: Maximum dose 174 mg every other day ( 2.6 ) • Mild hepatic impairment: Consider reducing the dose and/or frequency of dosing. ( 2.2 , 2.6 , 8.7 ) Renal Impairment • Consider reducing the do