3 known interactions • 2 major • 1 moderate • 0 minor
Always disclose all medications to your healthcare providers — prescription medicines, OTC medications, vitamins, and herbal supplements. This list may not include every possible interaction. Use our Medicine Interaction Checker to screen your complete medication list.
Potentially life-threatening or causing permanent damage. Avoid combination.
May worsen condition or require dose adjustment. Monitor closely.
Usually limited clinical effect. Manage with routine monitoring.
Benzodiazepines
Risk of severe respiratory depression and death
Management: Avoid concurrent use or use with extreme caution; patient must be closely monitored
CNS depressants
Additive CNS depression
Management: Avoid or use with caution; monitor closely for respiratory depression
CYP3A4 inhibitors
May increase buprenorphine levels
Management: Monitor for signs of overdose
Always ask your pharmacist about potential interactions with food, alcohol, and supplements specific to Buprenorphine. Some medicines have significant interactions with grapefruit juice, high-fat meals, dairy products, or vitamin K-rich foods.