No black box warning on record for D-16
As of the latest FDA labeling reviewed, D-16 (BLACK COHOSH, IRIS VERSICOLOR ROOT, SANGUINARIA CANADENSIS ROOT, GELSEMIUM SEMPERVIRENS ROOT, AND SPIGELIA ANTHELMIA) does not carry a black box warning. Standard warnings and precautions still apply — see the full D-16 medicine page for the complete safety profile.