Complete adverse effect profile including incidence rates and management
Important Safety Information
This is not a complete list of all possible side effects. Contact your healthcare provider if you experience any unexpected symptoms. For serious or life-threatening side effects, seek emergency medical attention immediately.
6 ADVERSE REACTIONS The following clinically significant adverse reactions are described elsewhere in the labeling: Gastrointestinal Perforations and Fistulae [see Warnings and Precautions (5.1) ] .
Surgery and Wound Healing Complications [see Warnings and Precautions (5.2) ] .
Hemorrhage [see Warnings and Precautions (5.3) ] .
Arterial Thromboembolic Events [see Warnings and Precautions (5.4) ] .
Venous Thromboembolic Events [see Warnings and Precautions (5.5) ] .
Hypertension [see Warnings and Precautions (5.6) ] .
Posterior Reversible Encephalopathy Syndrome [see Warnings and Precautions (5.7) ] .
Renal Injury and Proteinuria [see Warnings and Precautions (5.8) ] .
Infusion-Related Reactions [see Warnings and Precautions (5.9) ] .
Ovarian Failure [see Warnings and Precautions (5.11) ] .
5 WARNINGS AND PRECAUTIONS Gastrointestinal Perforations and Fistula : Discontinue for gastrointestinal perforations, tracheoesophageal fistula, Grade 4 fistula, or fistula formation involving any organ.
( 5.1 ) Surgery and Wound Healing Complications : In patients who experience wound healing complications during MVASI treatment, withhold MVASI until adequate wound healing.
Withhold for at least 28 days prior to elective surgery.
Do not administer MVASI for at least 28 days following a major surgery, and until adequate wound healing.
The safety of resumption of bevacizumab products after resolution of wound healing complication has not been established.
Like all medications, Mvasi can cause side effects. However, not everyone who takes this medication will experience them. Many side effects are dose-dependent and may improve as your body adjusts to the medication. Others may require dose adjustment or medical attention.
Contact your healthcare provider promptly if you experience:
Seek immediate emergency medical care if you experience signs of: