4 known interactions • 2 major • 2 moderate • 0 minor
Always disclose all medications to your healthcare providers — prescription medicines, OTC medications, vitamins, and herbal supplements. This list may not include every possible interaction. Use our Medicine Interaction Checker to screen your complete medication list.
Potentially life-threatening or causing permanent damage. Avoid combination.
May worsen condition or require dose adjustment. Monitor closely.
Usually limited clinical effect. Manage with routine monitoring.
CYP2D6 inhibitors (fluoxetine, paroxetine, quinidine, bupropion)
CYP2D6 inhibitors significantly increase aripiprazole plasma levels (2-fold increase), potentially causing dose-related toxicity (akathisia, somnolence, NMS risk).
Management: Reduce aripiprazole dose by 50% when a CYP2D6 inhibitor is added. Return to original dose when inhibitor is discontinued.
CYP3A4 inducers (carbamazepine, rifampin, phenytoin)
CYP3A4 inducers dramatically reduce aripiprazole levels (50% reduction), risking therapeutic failure (psychosis relapse).
Management: Double aripiprazole dose when CYP3A4 inducer is added. Return to original dose when inducer is discontinued.
CYP3A4 inhibitors (ketoconazole, itraconazole, clarithromycin)
CYP3A4 inhibitors increase aripiprazole exposure. When combined with CYP2D6 inhibition, the increase can be 3-fold.
Management: Reduce aripiprazole dose by 50%.
CNS depressants (alcohol, benzodiazepines, opioids)
Additive CNS depression and orthostatic hypotension.
Management: Use with caution; educate patient about additive sedation and fall risk.
Always ask your pharmacist about potential interactions with food, alcohol, and supplements specific to Aripiprazole. Some medicines have significant interactions with grapefruit juice, high-fat meals, dairy products, or vitamin K-rich foods.