Complete dosing information for aflibercept
Medical guidance required: Dosing information here is for educational purposes. Your healthcare provider will determine the appropriate dose based on your specific condition, kidney function, other medications, and medical history. Never adjust your dose without consulting your doctor or pharmacist.
Neovascular AMD: 2 mg (0.05 mL) intravitreally every 4 weeks for the first 3 months, then 2 mg every 8 weeks. An alternative dosing of every 12 weeks after the first year is supported by evidence. Diabetic Macular Edema: 2 mg every 4 weeks for 5 injections, then 2 mg every 8 weeks; may reduce to every 4 weeks based on disease activity. Diabetic Retinopathy: 2 mg every 4 weeks for 5 injections, then every 8 weeks. CRVO: 2 mg every 4 weeks. BRVO: 2 mg every 4 weeks for 6 months, then as needed.
Retinopathy of prematurity (ROP): 0.4 mg (0.01 mL) intravitreally as a single injection per eye; use is off-label in most markets.
No dose adjustment required; systemic exposure is minimal following intravitreal administration.
No dose adjustment required; systemic exposure is minimal following intravitreal administration.